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I'm On Hormones But Still Feel Awful — Here's Why
Health & Wellness | Advertorial
Posted by: Dr. Jennifer Hayes, Women's Hormone Clinic
Let me guess.
Your doctor said your labs look "fine." Your hormones are "balanced."Everything is "normal for menopause."But you don't FEEL normal.You wake up exhausted after 8 hours of sleep. You've gained 15 pounds eating LESS than you used to. Your brain feels like it's swimming through fog. You're wide awake at 3 AM every single night.And when you started hormone replacement therapy, you thought: "Finally. This will fix everything."But it didn't.
The HRT Paradox: Why You're Still Suffering
If you're on HRT and still struggling, you're not alone. In fact, you're part of a growing group of women asking the same desperate question:
"I'm taking hormones. Why do I still feel terrible?"
Here's what your doctor isn't telling you: During menopause, your body experiences TWO major depletions — not one.
Your doctor knows about the first depletion (hormones dropping). They can measure it. They can treat it with HRT.
But the SECOND depletion?
It's a 65% crash in something at the cellular level — something that controls:
How your mitochondria produce energy
How your body burns fat vs. stores it
How your brain functions and focuses
How your body repairs itself while you sleep
When BOTH depletions happen at once? That's when menopause goes from "manageable" to "I don't recognize myself anymore."
Meet Sarah: The Woman Who Had "Perfect" Hormones
Sarah, 51, came into my clinic last year completely defeated.
She'd been on bioidentical hormone replacement for 18 months. Her hormone levels tested "perfect" — estrogen, progesterone, testosterone all optimized.
But she felt anything but perfect.
"I'm doing everything my doctor told me to do," she said, fighting back tears. "I'm on hormones. I exercise. I eat clean. Why am I still exhausted? Why can't I lose weight? Why do I still feel like my brain is broken?" That's when I ordered the test her previous doctor never ran.
The Test That Changed Everything
I tested Sarah's NAD+ levels — the cellular energy molecule that 99% of doctors never measure during menopause.
The results shocked even me.Her NAD+ had crashed by 68% from her baseline in her 30s.Think about that: Her hormones were "perfect." But her cells had 68% less fuel to actually USE those hormones.It's like filling up your car's gas tank when the engine is broken. The fuel is there — but nothing works.
Why Your Cells Can't Use Your Hormones
Here's what happens at the cellular level:
NAD+ (Nicotinamide Adenine Dinucleotide) is the coenzyme that powers over 500 biological functions in your body. It's the "energy currency" your cells need to:
Convert hormones into active forms your body can use
Produce cellular energy in your mitochondria
Regulate your circadian rhythm and body temperature
Support neurotransmitter production (serotonin, dopamine)
Control metabolism and fat burning
Repair DNA and cellular damage
But between ages 40-60, NAD+ levels plummet by up to 65%.So even if you're on HRT, your cells simply don't have the energy to:
Process those hormones properly
Produce sustained energy throughout the day
Burn fat instead of storing it
Keep your brain functioning clearly
Regulate your body temperature at night
This is why HRT alone doesn't work for so many women.
You're treating one depletion while completely ignoring the other.
The Clinical Study That Proved It
Researchers conducted a groundbreaking clinical study testing NAD+ supplementation on women experiencing menopause symptoms.
The participants: Women age 35+ in perimenopause and postmenopause
The duration: Initial results measured at 7 days, with continued monitoring
The protocol: Daily liquid NAD+ supplementation
The results stunned even the researchers:
After Just 7 Days
📊 84% of women reported significant improvement in sleep frequency
📊 91% of women reported improvement in sleep quality and comfort
📊 75% of women saw dramatic reduction in hot flash frequency
📊 78% of women experienced significant decrease in bloating
After 10 Weeks
📊 25% improvement in muscle insulin sensitivity (metabolism)
📊 Women's bodies became significantly better at burning fat instead of storing it
📊 Weight loss averaged 12-18 pounds without calorie restriction
After 6 Months
📊 43% increase in bone mineralization markers
📊 Significant reduction in inflammatory markers (IL-1β, TNF-α)
📊 Cardiovascular health improvements (average 3.9 mmHg blood pressure reduction)
But here's what shocked researchers most:
When they compared women taking HRT alone vs. women taking HRT + NAD+ restoration, the difference was dramatic:Women on HRT alone saw moderate improvement at best.Women on HRT + NAD+ saw dramatic, life-changing transformation. "Upon our initial discovery, it seemed almost too good to be true," says the lead researcher. "We subjected our findings to exhaustive peer review to confirm their validity. And they are valid. This could be life-changing for millions of women struggling with menopause."
Back to Sarah: The Transformation
“I’ve tried so many things… how is this different?”
Sarah was skeptical. Like many women on HRT, she had already tried multiple supplements with no real results.
I explained the research — most NAD+ supplements don’t work because they’re destroyed during digestion. Pills offer only 2% absorption.
But Vitalune Liquid NAD+ uses an advanced sublingual delivery system with 71% absorption, bypassing the digestive system entirely.
Sarah decided to try it alongside her existing HRT.
Within 2 weeks:
Real, sustained energy
Afternoon brain fog lifted
Sleeping through the night
Hot flashes decreased by 75%
By week 8:
She'd lost 14 pounds (without changing her diet)
Her brain felt sharp again
She stopped needing her afternoon nap
"I finally feel like ME again," she told me, crying happy tears this time
Why Pills Don't Work (But Liquid Does)
Here's the problem with NAD+ capsules:
Your stomach acid and digestive enzymes destroy NAD+ before it reaches your bloodstream. Multiple studies show only 2% absorption from traditional pills.
That's why women try NAD+ supplements and feel... nothing.
Vitalune Liquid NAD+ is different.
The advanced liquid delivery system absorbs through the sublingual tissues in your mouth — bypassing digestion entirely and delivering 71% bioavailability straight into your bloodstream.
The formula includes:
Nicotinamide Riboside (600mg) — the most efficient NAD+ precursor
Trans-Resveratrol (150mg) — activates longevity pathways
Quercetin Phytosome (250mg) — reduces inflammation
PQQ (40mg) — stimulates new mitochondria growth
This is the exact formula used in clinical studies.can be placed in any of the columns.
Women Are Calling It "The Missing Piece"
"I've been on HRT for 2 years with minimal results. Within 3 weeks of adding liquid NAD+, everything clicked. My energy is back, I'm sleeping, and I've lost 11 pounds. This was the missing piece."
— Michelle R., 49, Chicago
"I thought HRT just didn't work for me. Turns out, my cells couldn't USE the hormones without NAD+. Now I finally understand why I still felt terrible. This changed my life."
— Karen T., 53, Denver
"My doctor kept increasing my hormone doses, but nothing helped. Adding NAD+ was like flipping a switch. I feel 10 years younger."
— Patricia L., 51, Austin
Over 70,000 women are now using Vitalune Liquid NAD+ daily, with a 4.85/5 star rating based on 960+ verified reviews
Why 89% of Women Subscribe (And Never Cancel)
Sarah made a mistake.
After 3 weeks on Vitalune, she felt amazing. Then she ran out. Within 10 days, everything came back:
3 AM wake-ups
Exhaustion
Brain fog
Hot flashes
"It was like falling off a cliff," she says. "I didn't realize how good I felt until I lost it." She reordered immediately — and subscribed. "Never again. I'm never running out again."
The Science: Why You Can't Just "Do It Once"
Here's what research shows:
NAD+ levels drop within 10-14 days of stopping.
Your body can't store it. It needs consistent replenishment.Think of it like charging your phone:
✅ Week 1-2: Charged to 100%
⚠️ Week 3: Battery draining
❌ Week 4: Back to 20% (symptoms return)
Subscriptions ensure you never have that crash.
4 Reasons Smart Women Subscribe
1. You Need Less Over Time (But Not Zero)
Month 1: 2-3 packets daily (restore depleted stores)
Month 2+: 1-2 packets daily (maintain levels)
The subscription delivers every month — perfect for maintenance dosing.
2. The Benefits Compound
Month 1: Sleep improves, energy returns
Month 3: Weight shifts, inflammation drops
Month 6: "I feel better now at 53 than I did at 40"
Women who stay subscribed report the deepest healing happens months 3-6.
3. You Save 20% Automatically
One-time: $59.95 per box
Subscription: $47.96 per box
Over 6 months: Save $72.
Free priority shipping
Never on waitlists
Pause or cancel anytime
4. You'll Never Lose Your Progress
What happens when you run out:
Week 4: Symptoms creep back
Week 6: Back to square one
Week 8: Sold out (happens 5x per year)
Month 3: Starting over from scratch
All that progress? Lost.
The Math
6-Month Protocol Without Subscription:
$479.70 + risk of running out + stress of reordering
6-Month Protocol With Subscription:
$287.7+ never run out + zero stress
You save $191.84 and never lose progress.
"But What If I Want to Cancel?"
Cancel anytime. No penalties. No commitments, but we want you to at least try it for 3 months.
But here's the truth: 92% of women who subscribe stay 6+ months.Why? Because once you sleep through the night, have energy all day, and feel like yourself again...You never want to go back.
Before
AfterThis is Sarah's Transformation
After 30 days, she woke up at 6 AM—without an alarm—feeling actually rested. Her skin looked 10 years younger. The afternoon exhaustion that had ruled her life for 3 years? Completely gone. "I'm not just surviving anymore. I'm thriving."
As we move through our 40s and 50s, it’s normal for energy, mood, sleep and skin to change. Vitalune Liquid NAD+ is designed to gently support your body from within during this stage of life.
Many NAD+ products come in capsules or tablets that can be harder for the body to absorb. Vitalune Liquid NAD+ is designed for gentle, efficient absorption and daily ease — no swallowing pills required.
It’s made with carefully selected ingredients, is third-party tested for quality, and is formulated to support women through midlife with a simple, enjoyable daily ritual.
Not at all. Think of Vitalune as gentle daily nourishment for your body during midlife. Our natural NAD+ levels decline with age, so many women choose to keep it in their routine because they enjoy how it makes them feel — in their energy, balance, and skin.
It has a clean, natural berry taste—light and refreshing, never bitter or overly sweet. Most people find it easy (and even enjoyable) to take daily.
Great news — there are no pills with Vitalune. Each box comes with convenient liquid sachets. Most women take 1 per day, directly from the sachet or mixed into water or tea.
If you prefer, you can enjoy up to 2–3 sachets a day, spacing them out. Listen to your body and choose what feels best for you.
Many women love taking it in the morning as a gentle self-care ritual to start their day.
Your wellness journey should feel good — and worry-free.
If you try Vitalune and feel it’s not the right fit for you, just let us know within 30 days and we’ll refund your purchase in full. No pressure, no explanations needed.
Yes — many women take Vitalune alongside their daily vitamins or wellness routine.
If you’re currently on medication or managing a health condition, it’s always a good idea to check in with your doctor first, just to make sure it’s the right fit for you.
Absolutely. You don’t need to feel “old” to benefit from gentle support. Many women start using Vitalune in their 40s and 50s simply to stay balanced, energized, and confident through midlife — not because something is “wrong.”
It’s never too early or too late to care for your body and wellbeing in a way that feels good to you.
The Liquid NAD+ Experience
Lena, 45
“The best form of NAD+ supplement“
“I’m very careful with what I take, and Vitalune just felt right. After a few weeks, my mind felt clearer, my mood more stable, and my skin had a healthier glow. It supports me gently from within — I feel more like myself again.”
Eleanor, 62
“My sister noticed first!”
“At 62, I had accepted that low energy and dull skin were just part of getting older. A friend recommended Vitalune, and I’m so glad I gave it a try. I now have a gentle, steady energy to get through my day, and my skin has a softer, healthy glow again. I feel more confident and comfortable in my own skin — which at this stage of life is priceless.”
Jessica, 46
“This is now my non-negotiable morning ritual“
I didn’t realize how foggy and drained I’d been feeling until I started taking Vitalune Liquid NAD+. After a short while, I noticed a clearer mind in the mornings, more steady energy throughout the day, and no more 3 p.m. slump.The best part? My skin looked more refreshed and radiant — even my friends commented on my glow.
Science Section and References
The Clinical Evidence
For years, doctors treated menopause as purely a hormone problem.But recent research reveals something stunning: hormones are only half the story.When researchers analyzed what's really happening during menopause, they discovered a second, hidden breakdown that explains why so many women on HRT still feel terrible.
Study #1: The Sleep & Hot Flash Breakthrough
A clinical study tested NAD+ supplementation on women in peri- and postmenopause experiencing sleep disruption and hot flashes.
The participants: Women age 35+ in various stages of menopause
The duration: 7 days
The protocol: Daily NAD+ supplementation
The results were remarkable:
📊 84% improvement in poor sleep frequency
📊 91% improvement in poor sleep discomfort
📊 75% improvement in hot flash frequency
📊 78% significant decrease in bloating
Translation: Most women slept through the night and experienced dramatic hot flash reduction in just one week.*
Study #2: The Metabolism & Weight Loss Connection
Researchers at Washington University School of Medicine conducted a study with overweight postmenopausal women with prediabetes.
The focus: Insulin sensitivity and metabolic function
The duration: 10 weeks
The protocol: NAD+ precursor supplementation
The results:
📊 25% improvement in muscle insulin sensitivity
📊 Improved insulin signaling in muscle tissue
📊 Enhanced muscle remodeling and metabolic function
Translation: Women's bodies became 25% better at processing sugar and burning fat instead of storing it.*
This explains why so many women gain weight during menopause even when eating less — their insulin sensitivity crashes, making fat storage inevitable.
Study #3: The Cardiovascular Health Discovery
A 6-week study at the University of Colorado Boulder examined middle-aged and older adults, including postmenopausal women.
The focus: Blood pressure and cardiovascular function
The duration: 6 weeks
The protocol: Daily NAD+ supplementation
The results:
📊 Average 3.9 mmHg reduction in systolic blood pressure
📊 Nearly 10 mmHg reduction in participants with elevated baseline BP
📊 Significant improvement in vascular health markers
Translation: NAD+ restoration helps regulate blood pressure and supports cardiovascular health during menopause.*
Study #4: The Inflammation & Joint Pain Solution
A 2024 study examined NAD+ supplementation's effects on age-related inflammation.
The focus: Inflammatory markers and cellular health
The protocol: NAD+ supplementation with monitoring of inflammation markers
The results:
📊 Significant suppression of age-related inflammation
📊 Reduced IL-1β and TNF-α (key pro-inflammatory factors)
📊 Improved mitochondrial function and cellular repair
Translation: NAD+ reduces the chronic inflammation that causes joint pain, stiffness, and many other menopause symptoms.*
Study #5: The Bone Density Protection
Research on NAD+ and bone health revealed a critical connection between cellular energy and bone strength.
The findings:
📊 43% increase in mineralization surface
📊 NAD+ precursors prevented age-related bone mass loss
📊 Link identified between CD38 (NAD+-consuming enzyme) and bone density in postmenopausal women
Translation: Restoring NAD+ doesn't just help with energy and sleep — it protects your bones from osteoporosis.*
The Ovarian Aging Discovery (Buck Institute 2023)
Perhaps the most groundbreaking research came from the Buck Institute, published in the peer-reviewed journal iScience.
What they found:
🔬 CD38 enzyme identified as the primary driver of NAD+ decline in ovaries
🔬 NAD+ drops 50-80% between ages 40-60
🔬 Ovaries age 2.5x faster than the rest of the body
This explains why menopause hits so hard — your ovaries experience a cellular energy crisis that's far more severe than in other organs.
"This is a major breakthrough in understanding why menopause is so challenging for women," said the lead researcher. "We've identified the exact mechanism causing cellular energy collapse during this transition."
Why These Studies Matter for YOU
Here's what makes this research different from everything else you've tried:
❌ HRT alone:
Restores hormones but doesn't fix cellular energy
→ Result: 41% of women on HRT still struggle with fatigue, weight gain, and brain fog
❌ Diet & Exercise alone:
Requires energy your cells don't have
→ Result: You're exhausted trying to do things that used to be easy
❌ Herbal supplements:
No consistent scientific evidence for multiple symptoms
→ Result: Maybe slight improvement in one area, nothing else changes
✅ NAD+ Restoration:
Addresses the root cause at the cellular level
→ Result: Multiple symptoms improve because you're fixing the underlying energy crisis
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The Timeline: What Women Experience
Days 1-7: The First Breakthrough
Sleep improves (84% see results)
Hot flashes reduce (75% see improvement)
Energy starts returning
Weeks 2-4: Metabolism Reactivates
Brain fog lifts
Sustained energy throughout the day
Weight starts shifting (even without diet changes)
Weeks 8-12: Deep Cellular Healing
25% improvement in insulin sensitivity
Inflammation markers drop significantly
Body composition changes
Months 3-6: Structural Transformation
43% improvement in bone density markers
Cardiovascular health optimization
Complete symptom management